Assessing T cell clonal size distribution: a non-parametric approach

Clonal structure of the human peripheral T-cell repertoire is shaped by a number of homeostatic mechanisms, including antigen presentation, cytokine and cell regulation. Its accurate tuning leads to a remarkable ability to combat pathogens in all their variety, while systemic failures may lead to severe consequences like autoimmune diseases. Here we develop and make use of a non-parametric statistical approach to assess T cell clonal size distributions from recent next generation sequencing data. For 41 healthy individuals and a patient with ankylosing spondylitis, who undergone treatment, we invariably find power law scaling over several decades and for the first time calculate quantitatively meaningful values of decay exponent. It has proved to be much the same among healthy donors, significantly different for an autoimmune patient before the therapy, and converging towards a typical value afterwards. We discuss implications of the findings for theoretical understanding and mathematical modeling of adaptive immunity.Comment: 13 pages, 3 figures, 2 table

Quantum jumps on Anderson attractors

In a closed single-particle quantum system, spatial disorder induces Anderson localization of eigenstates and halts wave propagation. The phenomenon is vulnerable to interaction with environment and decoherence, that is believed to restore normal diffusion. We demonstrate that for a class of experimentally feasible non-Hermitian dissipators, which admit signatures of localization in asymptotic states, quantum particle opts between diffusive and ballistic regimes, depending on the phase parameter of dissipators, with sticking about localization centers. In diffusive regime, statistics of quantum jumps is non-Poissonian and has a power-law interval, a footprint of intermittent locking in Anderson modes. Ballistic propagation reflects dispersion of an ordered lattice and introduces a new timescale for jumps with non-monotonous probability distribution. Hermitian dephasing dissipation makes localization features vanish, and Poissonian jump statistics along with normal diffusion are recovered.Comment: 6 pages, 5 figure

Photon waiting time distributions: a keyhole into dissipative quantum chaos

Open quantum systems can exhibit complex states, which classification and quantification is still not well resolved. The Kerr-nonlinear cavity, periodically modulated in time by coherent pumping of the intra-cavity photonic mode, is one of the examples. Unraveling the corresponding Markovian master equation into an ensemble of quantum trajectories and employing the recently proposed calculation of quantum Lyapunov exponents [I.I. Yusipov {\it et al.}, Chaos {\bf 29}, 063130 (2019)], we identify `chaotic' and `regular' regimes there. In particular, we show that chaotic regimes manifest an intermediate power-law asymptotics in the distribution of photon waiting times. This distribution can be retrieved by monitoring photon emission with a single-photon detector, so that chaotic and regular states can be discriminated without disturbing the intra-cavity dynamics.Comment: 7 pages, 5 figure

Anderson localization or nonlinear waves? A matter of probability

In linear disordered systems Anderson localization makes any wave packet stay localized for all times. Its fate in nonlinear disordered systems is under intense theoretical debate and experimental study. We resolve this dispute showing that at any small but finite nonlinearity (energy) value there is a finite probability for Anderson localization to break up and propagating nonlinear waves to take over. It increases with nonlinearity (energy) and reaches unity at a certain threshold, determined by the initial wave packet size. Moreover, the spreading probability stays finite also in the limit of infinite packet size at fixed total energy. These results are generalized to higher dimensions as well.Comment: 4 pages, 3 figure

Localization in periodically modulated speckle potentials

Disorder in a 1D quantum lattice induces Anderson localization of the eigenstates and drastically alters transport properties of the lattice. In the original Anderson model, the addition of a periodic driving increases, in a certain range of the driving's frequency and amplitude, localization length of the appearing Floquet eigenstates. We go beyond the uncorrelated disorder case and address the experimentally relevant situation when spatial correlations are present in the lattice potential. Their presence induces the creation of an effective mobility edge in the energy spectrum of the system. We find that a slow driving leads to resonant hybridization of the Floquet states, by increasing both the participation numbers and effective widths of the states in the strongly localized band and decreasing values of these characteristics for the states in the quasi-extended band. Strong driving homogenizes the bands, so that the Floquet states loose compactness and tend to be spatially smeared. In the basis of the stationary Hamiltonian, these states retain localization in terms of participation number but become de-localized and spectrum-wide in term of their effective widths. Signatures of thermalization are also observed.Comment: 6 pages, 3 figure

Control of a single-particle localization in open quantum systems

We investigate the possibility to control localization properties of the asymptotic state of an open quantum system with a tunable synthetic dissipation. The control mechanism relies on the matching between properties of dissipative operators, acting on neighboring sites and specified by a single control parameter, and the spatial phase structure of eigenstates of the system Hamiltonian. As a result, the latter coincide (or near coincide) with the dark states of the operators. In a disorder-free Hamiltonian with a flat band, one can either obtain a localized asymptotic state or populate whole flat and/or dispersive bands, depending on the value of the control parameter. In a disordered Anderson system, the asymptotic state can be localized anywhere in the spectrum of the Hamiltonian. The dissipative control is robust with respect to an additional local dephasing.Comment: 6 pages, 5 figure